RGD peptide GRGDNP( —— )

Catalog No. M30440 CAS No. 114681-65-1

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Datasheet

HNMR

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Product Name

RGD peptide GRGDNP
Note

Research use only, not for human use.
Brief Description

RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering.
Description

RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering.
In Vitro

RGD peptide (GRGDNP) (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs. RGD peptide (GRGDNP) (300?μg/mL; for 6?hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs.
In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

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Research Area

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Indication

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Ruoslahti, E., and ?brink, B. Common principles in cell adhesion Experimental Cell Research 227, 1-11 (1996).

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